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Phenethylamines: Structure, Function & Relevance

Phenethylamines are a diverse class of organic compounds based on the phenethylamine backbone, which consists of a benzene ring linked to an ethylamine chain. This simple structure serves as a foundation for a wide range of biologically active molecules, including neurotransmitters, stimulants, and psychedelics.

Chemical & Biological Features:

  • Core Structure: C₆H₅–CH₂–CH₂–NH₂ (phenethylamine)

  • Functional Diversity: Substitutions on the ring or side chain yield vastly different effects—from mood enhancement to sensory alteration.

  • Endogenous Role: Phenethylamine itself is naturally found in the human brain and acts as a neuromodulator.

Notable Subclasses:

SubclassExamplesPrimary Effects
StimulantsAmphetamine, MethamphetamineIncreased alertness, energy
PsychedelicsMescaline, 2C-B, DOMAltered perception, introspection
EntactogensMDMA (Ecstasy)Emotional openness, empathy
NootropicsSelegiline, Phenylpiracetam

Cognitive enhancement

Safety & Legal Status:

Phenethylamines vary widely in potency and legality. Some are prescription medications, while others are controlled substances or research chemicals. Responsible use and regulatory awareness are essential.